Compiler-aided systematic construction of large-scale DNA strand displacement circuits using unpurified components

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Compiler-aided systematic construction of large-scale DNA strand displacement circuits using unpurified components

Biochemical circuits made of rationally designed DNA molecules are proofs of concept for embedding control within complex molecular environments. They hold promise for transforming the current technologies in chemistry, biology, medicine and material science by introducing programmable and responsive behaviour to diverse molecular systems. As the transformative power of a technology depends on ...

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Functional Analysis of Large-Scale DNA Strand Displacement Circuits

We present a method for the analysis of functional properties of large-scale DNA strand displacement (DSD) circuits based on Satisfiability Modulo Theories that enables us to prove the functional correctness of DNA circuit designs for arbitrary inputs, and provides significantly improved scalability and expressivity over existing methods. We implement this method as an extension to the Visual D...

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DNA Strand-Displacement Timer Circuits.

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Analog Computation by DNA Strand Displacement Circuits.

DNA circuits have been widely used to develop biological computing devices because of their high programmability and versatility. Here, we propose an architecture for the systematic construction of DNA circuits for analog computation based on DNA strand displacement. The elementary gates in our architecture include addition, subtraction, and multiplication gates. The input and output of these g...

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Time-Complexity of Multilayered DNA Strand Displacement Circuits

Recently we have shown how molecular logic circuits with many components arranged in multiple layers can be built using DNA strand displacement reactions. The potential applications of this and similar technologies inspire the study of the computation time of multilayered molecular circuits. Using mass action kinetics to model DNA strand displacement-based circuits, we discuss how computation t...

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ژورنال

عنوان ژورنال: Nature Communications

سال: 2017

ISSN: 2041-1723

DOI: 10.1038/ncomms14373